In clinical trials, it was reported as a side effect by over 2% of users. If you feel any such thing after taking zoloft, make sure you don't have any blisters in your mouth that could contribute to this side effect. , MD, a primary care physician of Tenet Florida Physician Services and West Boca Medical Center. I've been on zoloft since 2004 and I've never had the side effect you describe. Always begin sertraline at the lowest dose, and increase slowly, reevaluating symptoms periodically, and using the lowest effective dose, says Dr. Perez-Vazquez. You feel extreme painful and burning sensation on your skin; . Zoloft Itching (An Irritating Side Effect) | OptimistMinds So if youre mildly feeling tingling or pins-and-needles sensation, its okay. Oh and my start up effects where hightened anxiety, panic attacks, sweaty palms and feet, loss of appetite, upset stomach, nausea, pins and needles feeling and burning sensation of the skin. , a patient may become suicidal, especially at the beginning of treatment and any time that the dose is increased or decreased. Sertraline may cause a serious condition called serotonin syndrome if taken together with some medicines. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Improper swallowing of pills can lead to serious complications if it accidentally goes into your windpipe. Canker sores are painful small blisters or ulcers which are found inside the mouth. For panic disorder, posttraumatic stress disorder, or social anxiety disorder: AdultsAt first, 25 milligrams (mg) once a day, taken either in the morning or evening. respect of any healthcare matters. You can try boiling a small piece of ginger in water for a few minutes. Zoloft is available in two forms, tablet and oral liquid form. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health.