Congenital cytomegalovirus and neonatal herpes simplex virus infections: to treat or not to treat?. These types include herpes simplex virus type 2 (HSV-2) and herpes simplex virus type 1 (HSV-1). Atopic dermatitis. Asymptomatic shedding of the virus in saliva or genital secretions can also lead to transmission of HSV, but this is infrequent, as the amount shed from inactive lesions is 100 to 1000 times less than when it is active. Verywell Health's content is for informational and educational purposes only. Both types of herpes simplex virus, HSV-1 and HSV-2, can cause oral or genital infection. Genital herpes is caused by two types of herpes simplex virus. 2019;38(6S):S60-S63. (n.d.). It may involve the iris. However, if the pattern of the lesions is not specific to HSV, its diagnosis can be made by viral culture, PCR, serology, direct fluorescent antibody testing, or Tzanck test. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Learn more about the Merck Manuals and our commitment to Global Medical Knowledge. If you have wet looking fluid-filled blisters in the vicinity of your mouth or genitals, chances are youve been infected with the herpes virus. 2016;529(7587):537-540. doi:10.1038/nature16506, Kaneko H, Kawana T, Ishioka K, Ohno S, Aoki K, Suzutani T. Evaluation of mixed infection cases with both herpes simplex virus types 1 and 2. Drinking and eating are painful, and the breath is foul. In patients with depressed cell-mediated immunity due to HIV infection or other conditions, prolonged or progressive lesions may persist for weeks or longer. Disseminated infection and/or persistent ulceration due to HSV can be serious in debilitated or immune deficient patients, for example in people with human immunodeficiency virus (HIV) infection. Most of these infections involve the oral mucosa or lips (herpes labialis). Where viral immunity is insufficient, recurrent infections are common, particularly with Type 2 genital herpes.
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