This document allows users see at-a-glance the risk and management of drug-drug interactions between Paxlovid and selected drugs that may be used in the outpatient setting. Fortunately, the patient was monitored in the ED for 24 hours, recovered, and was discharged home. This document gives details of the duration of the CYP3A4 inhibitory effect of ritonavir and guidance as to how to manage comedications that may have been paused or dose-adjusted during treatment with Paxlovid (nirmatrelvir/ritonavir). Study results show that nirmatrelvir and ritonavir may help people who have recently tested positive for coronavirus stay out of the hospital. WebManagement of Drug Interactions With Nirmatrelvir/Ritonavir (Paxlovid): Resource for Clinicians Facebook Twitter LinkedIn Email. We have produced various materials in PDF format to aid the use of experimental agents in the treatment of COVID-19. Paxlovid (nirmatrelvir tablets; ritonavir tablets), is the only oral agent officially endorsed by HHS, NIH, CDC, FDA for the ambulatory treatment of COVID-19. Please cite as: [Prescribing Resource Title], [PDF Publication Date], University of Liverpool, available from [33] Nirmatrelvir/ritonavir was found to be significantly effective in reducing the proportion of people with COVID-19-related hospitalization or death in this trial. Also, organizations should test their electronic health records and/or pharmacy computer systems to ensure they provide alerts for this and other drug-drug interactions. Adults 30 years or older identifying as First Nations people. In May 2022, Pfizer suggested repeating the treatment, but the FDA said there has been no evidence of benefit. [9] Exposure to nirmatrelvir/ritonavir was numerically lower in Japanese people than in Western individuals but not to a clinically meaningful extent. Does Paxlovid interact with my other drugs? <>/ExtGState<>/ColorSpace<>>>/Annots[60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R]/StructParents 4>> Eligible adults with mild to moderate COVID-19, confirmed by a positive polymerase chain reaction (PCR) test or a rapid antigen test (RAT), can be prescribed PBSsubsidised Paxlovid by their doctor or authorised nurse practitioner.
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