Do not inject into buttock. The best site for IM injection is the anterolateral aspect of the middle third of the thigh. As a central nervous system neurotransmitter, its a chemical messenger that helps transmit nerve signals across nerve endings to another nerve cell, muscle cell or gland cell. Place a tourniquet above the injection site and, after IM epinephrine is administered, inject up to 0.1 mL of epinephrine into the large local reaction site to slow absorption. It is recommended that you practise using the trainer device at least every three to four months. Epinephrine is the first line-medication of choice for treatment of anaphylaxis; it should be used in the same manner in pregnant and non-pregnant patients. Adrenaline injectors should be stored in a cool dark place at room temperature, but NOT refrigerated as this can damage the injector mechanism. If you are using the epinephrine injection in a child, make sure to hold his leg firmly in place and limit movement before and during an injection. Other parts of your nervous system are also involved, as well as other organ systems, hormones and neurotransmitters. In most situations, IM adrenaline is preferred and is safer than the intravenous (IV) route. Publication types Clinical Trial Randomized Controlled Trial Research Support, Non-U.S. Gov't Table. Doses of intramuscular 1:1000 adrenaline for anaphylaxis Adrenaline makes your heart beat faster and your lungs breathe more efficiently. If you do not start to feel better after 5 minutes, use a second adrenaline injector, if you have one. When administering to a child, to minimize the risk of injection related injury, hold the leg firmly in place and limit movement prior to and during an injection. Increased doses of epinephrine quicken the response, but some studies have shown that brain and heart damage are some of the side effects. Tremor. If breathing is difficult allow them to sit. Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection in the thigh [see Warnings and Precautions (5.2)]. Trouble sleeping. The outer thigh, versus the front of the thigh, is recommended because it provides a skin area with thinner tissue and less fat.
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